I ported the Game of Life that I made with Ofelia to OF.

https://golnative.handmadeproductions.de/

The advantage is that the .wasm filesize decreased from 12 to 1 MB.
Ofelia is great for using OF with Pure Data and for porting something fast to Emscripten.
But, if the Emscripten patch should be small and efficient (I think file size is a bigger concern), it makes sense to do the graphics directly in OF and the sound with ofxPd....